However, PKC comprises a family of 11 isoforms (Nishizuka, 2001), at least eight of which have been reported to be expressed in cerebellarPurkinje cells (Shimohama et al., 1990; Wetsel et al., 1992; Bareggi et al., 1996; Garcia and Harlan, 1997; Barmack et al., 2000). Constructing a molecular model of cerebellar LTD has been limited by the inability to identify the particular isoform(s) of PKC involved in LTD induction: to date, the only attempt to address this point directly has involved the creation of a PKC null mouse that shows normal cerebellar LTD (Chen et al., 1995)...
Там кстати, не случайно упомянут PDZ домен - один из важнейших белковых доменов постсинаптической плотности, да и всего синапса ;-)
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Date: 2009-01-16 09:31 am (UTC)Там кстати, не случайно упомянут PDZ домен - один из важнейших белковых доменов постсинаптической плотности, да и всего синапса ;-)